Evaluation of the synthesis process of SPIONs for MPI with different iron salts with MPS

Abstract

Tracers play a decisive role for the image quality in the MPI. The gold standard Resovist provides acceptable images, but not all of the iron in the Resovist contributes to signal generation. This results in a much higher amount of iron having to be injected into the organism than would be necessary for imaging. Although iron is one of the essential trace elements, it is toxic in higher doses. Therefore, tracer development must focus equally on improving image quality and reducing iron doses. This paper presents the standard method of co-precipitation with different iron salts. The different anions used have different ionic strengths and thus influence the crystal formation of the superparamagnetic magnetite.

Int. J. Mag. Part. Imag. 6(2), Suppl. 1, 2020, Article ID: 2009070, DOI: 10.18416/IJMPI.2020.2009070