International Journal on Magnetic Particle Imaging IJMPI
Vol. 2 No. 1 (2016): Int J Mag Part Imag

Research Articles

Diffusion-Controlled Synthesis of Magnetic Nanoparticles

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David Heinke (nanoPET Pharma GmbH, Berlin), Nicole Gehrke (nanoPET Pharma GmbH, Berlin), Daniel Schmidt (Physikalisch-Technische Bundesanstalt, Berlin), Uwe Steinhoff (Physikalisch-Technische Bundesanstalt, Berlin), Thilo Viereck (Institute of Electrical Measurement and Fundamental Electrical Engineering, Technical University Braunschweig), Hilke Remmer (Institute of Electrical Measurement and Fundamental Electrical Engineering, Technical University Braunschweig), Frank Ludwig (Institute of Electrical Measurement and Fundamental Electrical Engineering, Technical University Braunschweig), Mihály Pósfai (Department of Earth and Environmental Sciences, University of Pannonia, Veszprém), Andreas Briel (nanoPET Pharma GmbH, Berlin)

Copyright (c) 2016 David Heinke, Nicole Gehrke, Daniel Schmidt, Uwe Steinhoff, Thilo Viereck, Hilke Remmer, Frank Ludwig, Mihály Pósfai, Andreas Briel

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Technological advancements of the Magnetic Particle Imaging (MPI) scanner and image reconstruction are important steps in the process of bringing MPI to preclinical and clinical applications. The future of this promising imaging modality, however, also crucially relies on the development of MPI tracers with high performance. An interesting material, not only for MPI, encompasses biogenic iron oxide nanoparticles due to their superior magnetic properties. It is a fact, however, that the production of such particles is extremely challenging. A promising approach for their manufacture is through the application of biomimetic synthesis routes. In the present study, a diffusion-controlled synthesis of magnetic nanoparticles, mimicking certain aspects of biomineralization in vitro is presented. The particles’ structural as well as static and dynamic magnetic properties are characterized and their potential as an MPI tracer is investigated.

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