Functional MPI (fMPI) of hypercapnia in rodent brain with MPI time-series imaging

Konstantin Herb; Erica Mason; Eli Mattingly; Joseph Mandeville; Emiri Mandeville; Clarissa Cooley; Lawrence Wald

doi:10.18416/IJMPI.2020.2009009

International Journal on Magnetic Particle Imaging IJMPI
Vol. 6 No. 2 Suppl 1 (2020): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2020.2009009

Proceedings Articles

Functional MPI (fMPI) of hypercapnia in rodent brain with MPI time-series imaging

Konstantin Herb (Martinos Center for Biomedical Imaging, Harvard), Erica Mason (Martinos Center for Biomedical Imaging, Harvard), Eli Mattingly (Martinos Center for Biomedical Imaging, Harvard), Joseph Mandeville (Martinos Center for Biomedical Imaging, Harvard), Emiri Mandeville (Harvard Medical School), Clarissa Cooley (Martinos Center for Biomedical Imaging, Harvard), Lawrence Wald (Martinos Center for Biomedical Imaging, Harvard)

Abstract

MPI has been proposed as an alternative to fMRI for detecting cerebral blood volume (CBV) changes associated with brain activation due to potentially higher sensitivity, possibly enabling single-patient studies. In this work, we show preliminary neuroimaging data of CBV modulation with hypercapnia acquired in vivo on a rodent MPI scanner designed for time-series imaging. This continuously rotating 2D projection field free line imager enables time-series imaging with temporal resolution of up to 3 seconds. As a first demonstration of “fMPI”, we acquire time-series images of a rodent brain with 5 second temporal resolution with the animal undergoing alternating 3-minute periods of either hyper- or hypocapnia. Image intensity changes from CBV modulation of the injected SPIONs concentration were detected with a CNR of up to 14 in brain pixels.

Int. J. Mag. Part. Imag. 6(2), Suppl. 1, 2020, Article ID: 2009009, DOI: 10.18416/IJMPI.2020.2009009

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