International Journal on Magnetic Particle Imaging
Vol 6 No 2 Suppl. 1 (2020)
https://doi.org/10.18416/IJMPI.2020.2009001

Proceedings Articles

Encapsulation of new MPI tracer nanoparticles in the human red blood cells

Main Article Content

Antonella Antonelli (Università degli Studi di Urbino Carlo Bo), Patryk Szwargulski (Institute for Biomedical Imaging, Hamburg University of Technology), Emanuele-Salvatore Scarpa (Università degli Studi di Urbino Carlo Bo, Via Saffi 2, Urbino (PU), Italy), Cordula Gruettner (micromod Partikeltechnologie GmbH Friedrich-Barnewitz-Str. 4 D-18119 Rostock Tel. / Fax: +49 381 54345-614 / -620 http://www.micromod.de), Gianluca Ambrosi (Università degli Studi di Urbino Carlo Bo, Via Saffi 2, Urbino (PU), Italy), Loretta Guidi (Università degli Studi di Urbino Carlo Bo, Via Saffi 2, Urbino (PU), Italy), Tobias Knopp (Institute for Biomedical Imaging, Hamburg University of Technology), Mauro Magnani (Università degli Studi di Urbino Carlo Bo, Via Saffi 2, Urbino (PU), Italy)

Abstract

Although Magnetic Particle Imaging (MPI) is not yet in clinical use, it is highly promising for several medical applications, and especially for applications in diagnostic vascular in vivo imaging and imaging-guided vascular interventions. Furthermore, in the last years, different superparamagnetic iron oxide (SPIO) based contrast agents have been developed and approved for niche clinical applications in Magnetic Resonance Imaging (MRI) as alternative to Gadolinium-based contrast agents (GBCAs) due to the risk for patients suffering from kidney dysfunction or nephrogenic systemic fibrosis (NSF). Recently, the potential of RBCs loaded with different SPIO nanoparticles as blood-pool tracer agents with longer blood retention time for MRI and MPI has been investigated. Here, we report the first in vitro results with the highly efficient dextran-based MPI tracer particles perimag® and synomag®-D to study their eligibility to be encapsulated into human RBCs and the potential of these new SPIO-RBC constructs as tracer material for MPI. 
 
Int. J. Mag. Part. Imag. 6(2), Suppl. 1, 2020, Article ID: 2009001, DOI: 10.18416/IJMPI.2020.2009001

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