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Breast-conserving surgery (BCS) is a commonly utilized treatment for early stage breast cancers but has high reexcision rates due to post-surgery identification of positive margins. A fast, specific, sensitive, easy-to-use tool for assessing margins intraoperatively has been shown to reduce the need for additional surgeries, and while many techniques have been explored, the clinical need is still unmet. We assess Magnetic Particle Imaging (MPI) for intraoperative margin assessment in BCS, using a passively or actively tumor-targeted iron oxide agent and two hardware devices: a hand-held Magnetic Particle (MP) detector for identifying residual tumor in the breast, and a small-bore imager for quickly imaging the tumor distribution in the excised specimen. In this abstract, we present both hardware systems and demonstrate proof-of-concept detection and imaging of clinically-relevant phantoms.