International Journal on Magnetic Particle Imaging
Vol 8 No 1 Suppl 1 (2022): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2022.2203034

Proceedings Articles

A magnetic immunization method based on magnetic nanomarkers under the DC bias field

Main Article Content

Xinchao Cui  

Abstract

This paper investigates the effect of the SNR of the magnetic response harmonic signal on the sensitivity of biomolecular detection. A method is proposed for measuring the 2nd and 3rd harmonics of magnetic nanotags under a DC bias field, avoiding the influence of antimagnetic and paramagnetic substances around the magnetic nanotags, as well as the background magnetic field, on the 1st harmonic signal. Specific streptavidin-modified magnetic nanoparticles were used as measurement objects, and their binding to biotinylated polystyrene microspheres was measured by a prepared detection device to simulate the detection of specific biomolecules. Using the 2nd to 3rd harmonic ratio, the lower limit of detection of the lowest 4amol (0.4pM) polystyrene microspheres in a 100uL solution was eventually determined.

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