International Journal on Magnetic Particle Imaging
Vol 8 No 1 Suppl 1 (2022): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2022.2203036

Proceedings Articles

Magnetic signal evaluation and imaging of magnetic nanoparticles in brain phantom

Main Article Content

Masaomi Washino  (Advanced Technology R&D Center, Mitsubishi Electric Corp.), Kota Nomura  (Advanced Technology R&D Center, Mitsubishi Electric Corp.), Kazuki Yamauchi (Advanced Technology R&D Center, Mitsubishi Electric Corp.), Tetsuya Matsuda (Advanced Technology R&D Center, Mitsubishi Electric Corp.), Yasuaki Susumu (Advanced Technology R&D Center, Mitsubishi Electric Corp.), Satoshi Seino (Osaka University), Takashi Nakagawa (Osaka University), Toshiyasu Sakane (Kobe Pharmaceutical University), Toshihiko Kiwa  (Okayama University), Shun Tonooka  (Advanced Technology R&D Center, Mitsubishi Electric Corp.)

Abstract

Magnetic Particle Imaging (MPI) is an imaging modality that directly detects the nonlinear response of magnetic nanoparticles (MNPs). Spatial encoding is realized by saturating the magnetic moment of MNPs most everywhere except in the special point called the field free reagion in which magnetic field vanishes. Recently, it has been shown that the sensitivity of MPI can be improved by using a field free line (FFL) in which the field free region formed as a line. We developed a MPI equipmemt with FFL using a neodymium magnet and an iron yoke, and magnetic particle imaging of a mouse brain phantom was successfully performed. In addition, we studied the magnetization response of MNPs in the brain and found that the magnetic response of magnetic moment to external magnetic field in the brain is different from that in buffer solution.

Article Details

References

[1] B. Gleich and J. Weizenecker, Tomographic imaging using the nonlinear response of magnetic particles, Nature, Vol. 435, pp. 1214 -1217 (2005).
[2] T. Yoshida, S. Bai, A. Hirokawa, K. Tanabe, K. Enpuku, Dynamics of Magnetization and Easy Axis of Individual Ferromagnetic Nanoparticle Subject to Anisotropy and Thermal Fluctuations, J. Magn. Magn. Mat., 380, 105 (2015).
[3] R. M. Ferguson, K. R. Minard, and K. M. Krishnan, Optimization of nanoparticle core size for magnetic particle imaging, J. Magn. Magn. Mater, 321, 10 (2009).
[4] K. Murase, S. Hiratsuka, R. Song, and Y. Takeuchi, Development of a system for magnetic particle imaging using neodymium magnets and gradiometer, Japanese Journal of Applied Physics 53, 067001 (2014).
[5] K. Jinno, T. Kiwa et al., Magnetic characterization change by solutions of magnetic nanoparticles in liquid-phase magnetic immunoassay, AIP Advances 9, 125317 (2019).