International Journal on Magnetic Particle Imaging
Vol 8 No 1 Suppl 1 (2022): Int J Mag Part Imag

Short Abstracts

Imaging of the lumen of intracranial flow diverter stents with MPI

Main Article Content

Moriz Herzberg  , Martin Rückert  , Franziska Dorn , Thomas Kampf , Thorsten Bley  , Volker Behr  , Stefan Herz  , Patrick Vogel  

Abstract

Flow diverter (FD) for the endovascular treatment of intracranial aneurysms are an innovative new stent design. These nitinol stents modulate the turbulent inflow into an aneurysm, offering the potential of occlusion through thrombosis. After treatment follow-up imaging is necessary. Digital subtraction angiography is the gold-standard in follow-up of flow-diverters, yet its invasiveness with an 1% complication rate and patient exposure to ionizing radiation limit its application. The metallic stent material causes artifacts in computed tomography and magnetic resonance imaging compromising clinical interpretation. Magnetic particle imaging (MPI) is a fast and sensitive tomographic imaging modality that uses magnetic fields to visualize superparamagnetic iron-oxide nanoparticles (SPIOs). Inherent advantages of MPI are the background- and radiation-free visualization of tracer material. Thus, magnetic particle imaging (MPI) may be beneficial for patients with FD treated aneurysms. The aim of this work was to illustrate the feasibility of MPI visualizing the stent lumen of flow diverters in a phantom study

Article Details

References

M. Herzberg, F. Dorn, P. Dietrich, M.A. Rückert, T. Kampf, T.A. Bley et al., Magnetic particle imaging for artifact-free imaging of intracranial flow diverter stents: A phantom study, Physica Medica 88 (2021) 65–70.
[2] B.G. Thompson, R.D. Brown, S. Amin-Hanjani, J.P. Broderick, K.M. Cockroft, E.S. Connolly et al., Guidelines for the Management of Patients With Unruptured Intracranial Aneurysms: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association, Stroke 46 (2015) 2368–2400.
[3] T. Ingall, K. Asplund, M. Mähönen, R. Bonita, A multinational comparison of subarachnoid hemorrhage epidemiology in the WHO MONICA stroke study, Stroke 31 (2000) 1054–1061.
[4] M.A. Möhlenbruch, C. Herweh, L. Jestaedt, S. Stampfl, S. Schönenberger, P.A. Ringleb et al., The FRED flow-diverter stent for intracranial aneurysms: clinical study to assess safety and efficacy, AJNR. American journal of neuroradiology 36 (2015) 1155–1161.
[5] M. Patzig, R. Forbrig, L. Ertl, H. Brückmann, G. Fesl, Intracranial Aneurysms Treated by Flow-Diverting Stents: Long-Term Follow-Up with Contrast-Enhanced Magnetic Resonance Angiography, Cardiovascular and interventional radiology 40 (2017) 1713–1722.
[6] M. Graeser, F. Thieben, P. Szwargulski, F. Werner, N. Gdaniec, M. Boberg et al., Human-sized magnetic particle imaging for brain applications, Nature communications 10 (2019) 1936.
[7] E.U. Saritas, P.W. Goodwill, L.R. Croft, J.J. Konkle, K. Lu, B. Zheng et al., Magnetic particle imaging (MPI) for NMR and MRI researchers, Journal of magnetic resonance (San Diego, Calif. 1997) 229 (2013) 116–126.
[8] P. Vogel, M.A. Ruckert, P. Klauer, W.H. Kullmann, P.M. Jakob, V.C. Behr, Traveling wave magnetic particle imaging, IEEE transactions on medical imaging 33 (2014) 400–407.
[9] Y.H. Ding, T. Tieu, D.F. Kallmes, Experimental testing of a new generation of flow diverters in sidewall aneurysms in rabbits, AJNR. American journal of neuroradiology 36 (2015) 732–736.
[10] S. Herz, P. Vogel, P. Dietrich, T. Kampf, M.A. Rückert, R. Kickuth et al., Magnetic Particle Imaging Guided Real-Time Percutaneous Transluminal Angioplasty in a Phantom Model, Cardiovascular and interventional radiology 41 (2018) 1100–1105.
[11] J. Haegele, J. Rahmer, B. Gleich, J. Borgert, H. Wojtczyk, N. Panagiotopoulos et al., Magnetic particle imaging: visualization of instruments for cardiovascular intervention, Radiology 265 (2012) 933–938.
[12] S. Herz, P. Vogel, T. Kampf, P. Dietrich, S. Veldhoen, M.A. Rückert et al., Magnetic Particle Imaging-Guided Stenting, Journal of endovascular therapy an official journal of the International Society References
[1] M. Herzberg, F. Dorn, P. Dietrich, M.A. Rückert, T. Kampf, T.A. Bley et al., Magnetic particle imaging for artifact-free imaging of intracranial flow diverter stents: A phantom study, Physica Medica 88 (2021) 65–70.
[2] B.G. Thompson, R.D. Brown, S. Amin-Hanjani, J.P. Broderick, K.M. Cockroft, E.S. Connolly et al., Guidelines for the Management of Patients With Unruptured Intracranial Aneurysms: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association, Stroke 46 (2015) 2368–2400.
[3] T. Ingall, K. Asplund, M. Mähönen, R. Bonita, A multinational comparison of subarachnoid hemorrhage epidemiology in the WHO MONICA stroke study, Stroke 31 (2000) 1054–1061.
[4] M.A. Möhlenbruch, C. Herweh, L. Jestaedt, S. Stampfl, S. Schönenberger, P.A. Ringleb et al., The FRED flow-diverter stent for intracranial aneurysms: clinical study to assess safety and efficacy, AJNR. American journal of neuroradiology 36 (2015) 1155–1161.
[5] M. Patzig, R. Forbrig, L. Ertl, H. Brückmann, G. Fesl, Intracranial Aneurysms Treated by Flow-Diverting Stents: Long-Term Follow-Up with Contrast-Enhanced Magnetic Resonance Angiography, Cardiovascular and interventional radiology 40 (2017) 1713–1722.
[6] M. Graeser, F. Thieben, P. Szwargulski, F. Werner, N. Gdaniec, M. Boberg et al., Human-sized magnetic particle imaging for brain applications, Nature communications 10 (2019) 1936.
[7] E.U. Saritas, P.W. Goodwill, L.R. Croft, J.J. Konkle, K. Lu, B. Zheng et al., Magnetic particle imaging (MPI) for NMR and MRI researchers, Journal of magnetic resonance (San Diego, Calif. 1997) 229 (2013) 116–126.
[8] P. Vogel, M.A. Ruckert, P. Klauer, W.H. Kullmann, P.M. Jakob, V.C. Behr, Traveling wave magnetic particle imaging, IEEE transactions on medical imaging 33 (2014) 400–407.
[9] Y.H. Ding, T. Tieu, D.F. Kallmes, Experimental testing of a new generation of flow diverters in sidewall aneurysms in rabbits, AJNR. American journal of neuroradiology 36 (2015) 732–736.
[10] S. Herz, P. Vogel, P. Dietrich, T. Kampf, M.A. Rückert, R. Kickuth et al., Magnetic Particle Imaging Guided Real-Time Percutaneous Transluminal Angioplasty in a Phantom Model, Cardiovascular and interventional radiology 41 (2018) 1100–1105.
[11] J. Haegele, J. Rahmer, B. Gleich, J. Borgert, H. Wojtczyk, N. Panagiotopoulos et al., Magnetic particle imaging: visualization of instruments for cardiovascular intervention, Radiology 265 (2012) 933–938.
[12] S. Herz, P. Vogel, T. Kampf, P. Dietrich, S. Veldhoen, M.A. Rückert et al., Magnetic Particle Imaging-Guided Stenting, Journal of endovascular therapy an official journal of the International Society of Endovascular Specialists (2019) 1526602819851202.
[13] F. Wegner, T. Friedrich, N. Panagiotopoulos, S. Valmaa, J.P. Goltz, F.M. Vogt et al., First heating measurements of endovascular stents in magnetic particle imaging, Physics in medicine and biology 63 (2018) 45005.

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