MPS and MRI efficacy of magnetosomes from wild-type and mutant bacterial strains

David Heinke; Alexander Kraupner; Dietmar Eberbeck; Daniel Schmidt; Patricia Radon; René Uebe; Dirk Schüler; Andreas Briel

International Journal on Magnetic Particle Imaging IJMPI
Vol. 3 No. 2 (2017): Int J Mag Part Imag

Research Articles

MPS and MRI efficacy of magnetosomes from wild-type and mutant bacterial strains

David Heinke (nanoPET Pharma GmbH), Alexander Kraupner (nanoPET Pharma GmbH), Dietmar Eberbeck (Physikalisch-Technische Bundesanstalt), Daniel Schmidt (Physikalisch-Technische Bundesanstalt), Patricia Radon (Physikalisch-Technische Bundesanstalt), René Uebe (University of Bayreuth), Dirk Schüler (University of Bayreuth), Andreas Briel (nanoPET Pharma GmbH)

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

The future of Magnetic Particle Imaging (MPI), as a tracer-based imaging modality, crucially relies on the development of high-performing tracers. Due to their ideal structural and magnetic properties, biogenic nanoparticles extracted from magnetotactic bacteria are promising candidates for MPI tracer research. In the present study we investigate the potential of bacterial magnetosomes, extracted from wild-type bacteria of the strain Magnetospirillum gryphiswaldense and various mutants thereof, as new tracer materials for MPI. Furthermore, we investigate the structural and magnetic properties of the magnetosomes as well as their suitability as Magnetic Resonance Imaging (MRI) agents in order to explain differences in MPI and MRI efficacies.

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