Validation of spatial selectivity enhancement for magnetic fluid hyperthermia by introducing ferromagnetic cores

Abstract

Spatial selectivity plays a crucial role in magnetic fluid hyperthermia because it can define the precision of thermal dose localization and spatial resolution. We propose an application of additional ferromagnetic cores, with high magnetic permeability, to confine the magnetic flux of the selection field coil. An increased gradient leads to increasing spatial selectivity in theranostic therapy of MPI-assisted magnetic fluid hyperthermia. This work validates our recent simulation study [1] by actual experiments of iron core prototypes. This study shows that our core prototypes can increase the gradient by a factor of 1.3 which suggests a 21% improvement in thermal localization in hyperthermia therapy.