International Journal on Magnetic Particle Imaging
Vol 8 No 1 Suppl 1 (2022): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2022.2203009

Proceedings Articles

Effect of the PEG functionalization on the saturation magnetization of magnetic nanoporous core-shell nanoparticles

Main Article Content

Timo Herrmann  (Leibniz University Hannover, Germany), Arne Klaus Schierz  (Leibniz Universität Hannover), Maren Prediger  (Leibniz Universität Hannover), Janin Reifenrath  , Jessica Meißner , Marc Christopher Wurz (Ulm University), Peter Behrens  

Abstract

The treatment of implant-associated infection is still a considerable issue in modern orthopaedical surgery. A promising candidate to improve this are superparamagnetic, drug loaded nanoparticles in combination with a magnetizable implant and an external magnetic field. This set-up enhances the accumulation of the magnetic nanoparticles at the targeted implant, thus reducing the number of nanoparticles needed for a successful treatment. Pivotal for the superparamagnetic nanoparticles are a preferably high magnetization and a sufficient long circulation time within the body. A poly(ethyleneglycol) (PEG) functionalization is widely used to increase the circulation time. Since a PEG functionalization adds mass to a nanoparticle, which influence its properties, we functionalized magnetic nanoporous silica nanoparticles (MNPSNP) with PEG moieties of different chain length and studied the effect of the chain length of the saturation magnetization on the particles.

Article Details

References

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