International Journal on Magnetic Particle Imaging
Vol 8 No 1 Suppl 1 (2022): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2022.2203006

Proceedings Articles

Magnetic Microspheres for MPI and magnetic actuation

Main Article Content

Diana Zahn  (Institute of Biomedical Engineering and Informatics (BMTI), Technische Universität Ilmenau), Justin Ackers  (Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering IMTE, Lübeck, Germany), Silvio Dutz  (Institute of Biomedical Engineering and Informatics (BMTI), Technische Universität Ilmenau, Germany), Thorsten Buzug (Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering IMTE, Lübeck, Germany), Matthias Graeser  (Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering IMTE, Lübeck, Germany)

Abstract

Magnetic particle imaging (MPI) systems do not only allow for the visualization of the distribution of magnetic nanoparticles, but the magnetic fields of an MPI scanner can be also used to apply a magnetic force or a torque. This enables the actuation of magnetic particles. Here, we demonstrate that magnetic microspheres (MMS) are well suitable candidates for the actuation and visualization with MPI. By means of magnetic particle spectrometer (MPS) measurements, a promising imaging performance of the MMS for MPI was confirmed. We show that MMS can be actuated by rotating focus fields of a preclinical MPI scanner. Since the used MMS can carry therapeutics, which can be released by means of hyperthermia, this approach paves the way towards an MPI monitored targeted drug delivery.

Article Details