International Journal on Magnetic Particle Imaging IJMPI
Vol. 9 No. 1 Suppl 1 (2023): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2023.2303045

Proceedings Articles

Safe and Rapid 3D Imaging: Upgrade of a Human-Sized Brain MPI System

Main Article Content

Florian Thieben (Section for Biomedical Imaging, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute for Biomedical Imaging, Hamburg University of Technology, Hamburg, Germany), Fabian Mohn (Section for Biomedical Imaging, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute for Biomedical Imaging, Hamburg University of Technology, Hamburg, Germany), Fynn Foerger (Section for Biomedical Imaging, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute for Biomedical Imaging, Hamburg University of Technology, Hamburg, Germany), Niklas Hackelberg (Section for Biomedical Imaging, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute for Biomedical Imaging, Hamburg University of Technology, Hamburg, Germany), Jan-Philipp Scheel (Fraunhofer Research Institute for Individualized and Cell-based Medicine, Lübeck, Germany; Institute for Medical Engineering, University of Lübeck, Lübeck, Germany), Matthias Graeser (Section for Biomedical Imaging, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute for Biomedical Imaging, Hamburg University of Technology, Hamburg, Germany; Fraunhofer Research Institute for Individualized and Cell-based Medicine, Lübeck, Germany; Institute for Medical Engineering, University of Lübeck, Lübeck, Germany), Tobias Knopp (Section for Biomedical Imaging, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute for Biomedical Imaging, Hamburg University of Technology, Hamburg, Germany)

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Abstract

Magnetic Particle Imaging hardware has reached human scale and thus patient safety questions and clinical application scenarios are in the focus of current research. In this work, we present a safe real-time 3D MPI system
for cerebral applications. High voltages are avoided to ensure patient safety by a low voltage-high current transmit coil design. The developed 2D drive-field generator generates a field-free-point trajectory in the sagittal xz-plane
that is shifted by a dynamic selection-field sequence along the y-axis. The scanner generates 3D images with 4 frames/second and allows for direct visualization of the clinically preferred transversal yz-plane, which is crucial
for future brain examinations. Advanced reconstruction techniques reach a system sensitivity of 4 ?gFe with respect to the iron mass in a sensitivity study.

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