International Journal on Magnetic Particle Imaging IJMPI
Vol. 9 No. 1 Suppl 1 (2023): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2023.2303046

Proceedings Articles

A Development of 3D navigation system for micro-nano robot based on a Magnetic Particle Imaging system

Main Article Content

Minh Phu Bui (School of Integrated Technology, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea), Myeongjin Park , Tuan-Anh Le (School of Integrated Technology, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea), Jungwon Yoon 

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

The 3D navigation system of micro-nano robot based on magnetic particle imaging is a promising technique to be used for targeted drug delivery. Using the magnetic actuator by manipulating field free point (FFP) and non-invasive molecular imaging method such magnetic particle imaging, the device can reduce the harm in treatment. In this paper, we used closed-loop control to steer a micro robot to a desired position by a 3D FFP magnetic force based system. A custom-built MPI system with a bore size of 90 mm that can generate a gradient as high as 4T/m/µ0 was used to verify the control system in three dimensions.

Article Details

References

[1] M. P. Bui, T. A. Le, and J. Yoon, “A Magnetic Particle Imaging-Based Navigation Platform for Magnetic Nanoparticles Using Interactive Manipulation of a Virtual Field Free Point to Ensure Targeted Drug Delivery,” IEEE Trans. Ind. Electron., vol. 68, no. 12, pp. 12493–12503, 2021, doi: 10.1109/TIE.2020.3039219.
[2] M. Park, T. A. Le, and J. Yoon, “Offline Programming Guidance for Swarm Steering of Micro-/Nano Magnetic Particles in a Dynamic Multichannel Vascular Model,” IEEE Robot. Autom. Lett., vol. 7, no. 2, pp. 3977–3984, 2022, doi: 10.1109/LRA.2022.3148789.
[3] X. Dong, S. Kheiri, Y. Lu, Z. Xu, M. Zhen, and X. Liu, “Toward a living soft microrobot through optogenetic locomotion control of Caenorhabditis elegans,” Sci. Robot., vol. 6, no. 55, pp. 1–15, 2021, doi: 10.1126/scirobotics.abe3950.
[4] M. P. Bui, T. A. Le, and J. Yoon, “Development of Rat-Scale Magnetic Particle Spectroscopy for Functional Magnetic Particle Imaging,” IEEE Magn. Lett., vol. 11, pp. 3–7, 2020, doi: 10.1109/LMAG.2020.2968407.
[5] T. A. Le, M. P. Bui, and J. Yoon, “Development of Small Rabbit-scale Three-dimensional Magnetic Particle Imaging System with Amplitude Modulation Based Reconstruction,” IEEE Trans. Ind. Electron., vol. 0046, no. c, 2022, doi: 10.1109/TIE.2022.3169715.
[6] D. Folio and A. Ferreira, “Two-dimensional robust magnetic resonance navigation of a ferromagnetic microrobot using Pareto optimality,” IEEE Trans. Robot., vol. 33, no. 3, pp. 583–593, 2017, doi: 10.1109/TRO.2016.2638446.
[7] M. Sitti et al., “Biomedical Applications of Untethered Mobile Milli/Microrobots,” Proc. IEEE, vol. 103, no. 2, pp. 205–224, 2015, doi: 10.1109/JPROC.2014.2385105.
[8] N.-S. Cheng, “Formula for the Viscosity of a Glycerol?Water Mixture,” Ind. Eng. Chem. Res., vol. 47, no. 9, pp. 3285–3288, May 2008, doi: 10.1021/ie071349z.
[9] A. G. Hudetz, “Blood flow in the cerebral capillary network: A review emphasizing observations with intravital microscopy,” Microcirculation, vol. 4, no. 2, pp. 233–252, 1997, doi: 10.3109/10739689709146787.