Multi-contrast MPI channel leakage reduction using a two-step measurement and reconstruction method

Abstract

Magnetic particle imaging (MPI) is an imaging modality that measures the response of magnetic nanoparticle tracers
to alternating magnetic fields. There has recently been exploration into multi-contrast MPI, in which the signal
from different tracer materials or environments is separately reconstructed, resulting in multi-channel images that
enable temperature or viscosity quantification. In this work, we investigate the channel leakage in multi-contrast
MPI reconstruction and we introduce a two-step measurement and reconstruction method to quantify and reduce
channel leakage between multi-contrast MPI channels.