International Journal on Magnetic Particle Imaging IJMPI
Vol. 11 No. 1 Suppl 1 (2025): Int J Mag Part Imag

Short Abstracts

Degradation characteristics of PLA-based medical implant markers for Magnetic Particle Imaging

Main Article Content

Patrick Naoki Elfers (Institute for Interventional Radiology, University Hospital Schleswig-Holstein, Lübeck), Kerstin Lüdtke-Buzug (Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering IMTE; University of Lübeck, Institute of Medical Engineering), Ankit Malhotra (Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering IMTE), Justin Ackers (Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering IMTE), Liana Mirzojan (Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering IMTE; University of Lübeck, Institute of Medical Engineering), Maximilian Wattenberg (Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering IMTE), Johann Christopher Engster (Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering IMTE), David Melenberg (Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering IMTE), Mandy Ahlborg (Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering IMTE), Thomas Friedrich (Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering IMTE), Maria-Josephina Buhné (Institute of Radiology and Nuclear Medicine, University Hospital Schleswig-Holstein, Lübeck), Malte Maria Sieren (Institute of Radiology and Nuclear Medicine/Institute for Interventional Radiology, University Hospital Schleswig-Holstein, Lübeck), Thorsten M. Buzug (Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering IMTE; University of Lübeck, Institute of Medical Engineering), Roman Kloeckner (Institute for Interventional Radiology, University Hospital Schleswig-Holstein, Lübeck), Jörg Barkhausen (Institute of Radiology and Nuclear Medicine, University Hospital Schleswig-Holstein, Lübeck), Franz Wegner (Institute for Interventional Radiology, University Hospital Schleswig-Holstein, Lübeck; Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering IMTE)

Copyright (c) 2025 Patrick Naoki Elfers, Kerstin Lüdtke-Buzug, Ankit Malhotra, Justin Ackers, Liana Mirzojan, Maximilian Wattenberg, Johann Christopher Engster, David Melenberg, Mandy Ahlborg, Thomas Friedrich, Maria-Josephina Buhné, Malte Maria Sieren, Thorsten M. Buzug, Roman Kloeckner, Jörg Barkhausen, Franz Wegner

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Potential clinical applications for Magnetic Particle Imaging (MPI) include cardiovascular imaging and endovascular interventions. To visualize medical instruments in MPI, permanent marking technologies have been developed. However, to prevent artefacts during follow-up examinations, temporary markers are of interest, e.g. for postinterventional stent lumen quantification. In this work, biodegradable medical instrument markers, based on polylactic acid (PLA) and superparamagnetic iron-oxide nanoparticles (SPIONs), have been developed. The markers’ signal characteristics and degradation were investigated over a period of 28 d in a water bath at 37 °C. Analysis was conducted using a laboratory scale, Micro-CT, microscopy, Magnetic Particle Spectroscopy (MPS), MPI and Vibrating Sample Magnetometry (VSM). The mass of the markers decreased by ~90% after 28 d. However, no signal loss or relevant loss of SPIONs was detected. This contradictory behavior is surprising and requires further investigation.

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