Enzyme-powered magnetic nanomotors for magnetic particle imaging and magnetic fluid hyperthermia

Huimin Wei; Justin Ackers; Juan Fraire; Samuel Sánchez; Anna C. Bakenecker

International Journal on Magnetic Particle Imaging IJMPI
Vol. 11 No. 1 Suppl 1 (2025): Int J Mag Part Imag

Short Abstracts

Enzyme-powered magnetic nanomotors for magnetic particle imaging and magnetic fluid hyperthermia

Huimin Wei (Fraunhofer IMTE), Justin Ackers (Fraunhofer IMTE, Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering, Lübeck, Germany), Juan Fraire (Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain), Samuel Sánchez (1) Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain; 2) Catalan Institute for Research and Advanced Studies (ICREA), Barcelona, Spain), Anna C. Bakenecker (1) Fraunhofer IMTE, Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering, Lübeck, Germany; 2)Medical Engineering, Department of Electrical Engineering and Information Technology, Technical University of Darmstadt, 64283 Darmstadt, Germany)

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Magnetic fluid hyperthermia (MFH) is a promising cancer therapy that relies on the heat dissipation of magnetic nanoparticles. To enhance the efficiency of MFH, materials with improved penetration and diffusion properties are required. Self-propelled nanomotors (NMs), driven by catalytic reactions, offer significant potential in this regard. Urease-powered nanomotors have demonstrated enhanced accumulation in tumors and improved therapeutic outcomes. This work presents a novel urease-powered magnetic nanomotor that functions as both a tracer for magnetic particle imaging (MPI) and a magnetic material for hyperthermia. The proposed nanomotor exhibits efficient diffusion and magnetic heating, making it an ideal candidate for MPI-assisted MFH therapy.

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