International Journal on Magnetic Particle Imaging IJMPI
Vol. 11 No. 1 Suppl 1 (2025): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2025.2503050

Proceedings Articles

Magnetic Particle Spectrometry of 3D cancer cell spheroids

Main Article Content

Lea Antonia Rossa (Fraunhofer IMTE, Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering, Mönkhofer Weg 239a, 23562 Lübeck, Germany), Huimin Wei (Fraunhofer IMTE, Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering, Mönkhofer Weg 239a, 23562 Lübeck, Germany), Heiko Lemcke (1) Clinic for Cardiac Surgery, Research Building BMFZ, Schillingallee 69, 18057 Rostock, Germany; 2) Department of Life, Light & Matter (LL & M), Albert-Einstein-Str. 25, 18059 Rostock, Germany), Matthias Brandenburger (Fraunhofer IMTE, Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering, Mönkhofer Weg 239a, 23562 Lübeck, Germany), Anna C. Bakenecker (1) Fraunhofer IMTE, Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering, Mönkhofer Weg 239a, 23562 Lübeck, Germany; 2) Medical Engineering, Department of Electrical Engineering and Information Technology, Technical University of Darmstadt, 64283 Darmstadt, Germany)

Copyright (c) 2025 Lea Antonia Rossa, Huimin Wei, Heiko Lemcke, Matthias Brandenburger, Anna C. Bakenecker

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs) have a significant role in biomedical applications such
as hyperthermia therapy or magnetic particle imaging. This study investigates the loading of 3D cell spheroids
made from a pancreas cell line of rats with magnetic nanoparticles. Here, we show the uptake and a homogeneous
distribution of nanoparticles in spheroids, while magnetic particle spectrometry (MPS) reveals a measurable
difference in the magnetic behavior of nanoparticles in aqueous solution compared to those incorporated into
spheroids.

Article Details

Most read articles by the same author(s)

<< < 1 2