International Journal on Magnetic Particle Imaging IJMPI
Vol. 11 No. 1 Suppl 1 (2025): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2025.2503034

Proceedings Articles

Hybrid supraparticles for combined MPI and magnetic hyperthermia

Main Article Content

Stephan Müssig (Professorship for Inorganic Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg), Justin Ackers (Fraunhofer-Einrichtung für Individualisierte und Zellbasierte Medizintechnik IMTE), Eric Aderhold (Fraunhofer IMTE), Markus Heinlein (Professorship for Inorganic Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg), Bruno Kluwe (Fraunhofer IMTE), Huimin Wei (Fraunhofer IMTE), Karl Mandel (1) Professorship for Inorganic Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg;2) Fraunhofer ISC), Anna C. Bakenecker (1) Fraunhofer IMTE; 2) Medical Engineering, Department of Electrical Engineering and Information Technology, Technical University of Darmstadt)

Copyright (c) 2025 Stephan Müssig, Justin Ackers, Eric Aderhold, Markus Heinlein, Bruno Kluwe, Huimin Wei, Karl Mandel, Anna C. Bakenecker

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Combining magnetic particle imaging (MPI) with magnetic hyperthermia in a single location opens new effective
theranostic applications, e.g. in targeted cancer therapy. We present the utilization of hybrid supraparticles con-
taining two nanoparticle species to create particles with optimized magnetic properties for both technologies. For
this, ferromagnetic particles, which are known for their good performance for hyperthermia are combined with
superparamagnetic particles, which are very well suitable for MPI. The supraparticles are characterized regarding
their MPS spectra and heating power during magnetic hyperthermia. Additionally, first experiments demonstrate
the feasibility of the approach also for imaging. The results represent a proof-of-concept for the supraparticle
approach, which will facilitate the optimization of particle properties for both technnologies at the same time.

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