Transmission magnetic particle optical scanning imaging

Abstract

Magnetic nanoparticles (MNPs) are widely used in biological magnetic imaging such as Magnetic Particle Imaging (MPI) and Magnetic Resonance Imaging (MRI) due to their unique magnetic and chemical properties. However, traditional magnetic imaging often comes with resolution limitations, which are typically determined by the strength of the magnetic field and the ability to spatially encode the magnetic field. To overcome the limitations of spatial resolution, we propose using optical scanning for imaging, which can achieve high imaging resolution while retaining a certain degree of penetration capability. The experimental results show that using optical scanning for MNPs imaging can achieve a resolution of 125 microns in magneto-optical signals within a 5cm * 5cm imaging range, and can penetrate 1mg/ml MNPs solution with a thickness of 1cm. The proposal of this method presents a new approach for high-precision human imaging in the future.