International Journal on Magnetic Particle Imaging IJMPI
Vol. 11 No. 1 Suppl 1 (2025): Int J Mag Part Imag
Signal characteristics of the clinically approved tracer Resotran in MPI and MRI
Main Article Content
Copyright (c) 2025 Maria-Josephina Buhné, Justin Ackers, Eric Aderhold, Kerstin Luedtke-Buzug, Mandy Ahlborg, Matthias Graeser, Jonas Stroeder, Roman Kloeckner, Thorsten Buzug, Jörg Barkhausen, Alex Frydrychowicz, Franz Wegner

This work is licensed under a Creative Commons Attribution 4.0 International License.
Abstract
Potential medical applications for Magnetic Particle Imaging (MPI) are diverse. Especially, cardiovascular and cerebral perfusion imaging as well as the monitoring of endovascular interventions are very promising. With the approval of the Ferucarbotran-based tracer Resotran, a big hurdle on the way to clinical MPI has been overcome. A key characteristic of Resotran is the possibility of using it as a bimodal tracer for MPI and MRI. In this work, we tested the signal performance of Resotran in both preclinical MPI and clinical MRI.
Article Details
References
[2] Vaalma S et al., Magnetic particle imaging (MPI): ex- perimental quantification of vascular stenosis using stationary stenosis phantoms. PLoS ONE 12(1):e168902.
[3] Wegner F et al., Magnetic particle imaging: in vitro signal analysis and lumen quantification of 21 endovascular stents. Int J Nanomedicine 16:213–221.
[4] Mohn F al., Characterization of the clinically approved MRI tracer resotran for magnetic particle imaging in a comparison study, Phys. Med. Biol. 69 135014
[5] Biederer S et al., Magnetization response spectroscopy of superparamagnetic nanoparticles for magnetic particle imaging, J. Phys. D: Appl. Phys. 42 205007
[6] J. Franke et al., "Hybrid MPI-MRI System for Dual-Modal In Situ Cardiovascular Assessments of Real-Time 3D Blood Flow Quantification - A Pre-Clinical In Vivo Feasibility Investigation," in IEEE Transactions on Medical Imaging, vol. 39, no. 12, pp. 4335-4345, Dec. 2020 [7] P. Vogel et al., "MRI Meets MPI: A Bimodal MPI-MRI Tomograph," in IEEE Transactions on Medical Imaging, vol. 33, no. 10, pp. 1954-1959, Oct. 2014
[8] Salamon J et al., Visualization of spatial and temporal temperature distributions with magnetic particle imaging for liver tumor ablation therapy, Sci Rep (2020) 10:7480
[9] Wegner et al., Bimodal Interventional Instrument Markers for Magnetic Particle Imaging and Magnetic Resonance Imaging—A Proof of-Concept Study Nanomaterials 2022, 12(10),1758