International Journal on Magnetic Particle Imaging IJMPI
Vol. 11 No. 1 Suppl 1 (2025): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2025.2503005

Proceedings Articles

Dual-frequency MPS enables direct MNP size reconstruction: Verification with micromagnetic simulation data

Main Article Content

Timur Bikulov (Forschungszentrum Jülich), Mohamad-Bilal Abbas (Department of Medical Engineering and Applied Mathematics, FH Aachen University of Applied Sciences, Jülich, Germany), Hans-Joachim Krause (Institute of Biological Information Processing, Forschungszentrum Jülich, Jülich, Germany), Andreas Offenhäusser (Institute of Biological Information Processing, Forschungszentrum Jülich, Jülich, Germany), Ulrich Engelmann (Department of Medical Engineering and Applied Mathematics, FH Aachen University of Applied Sciences, Jülich, Germany)

Copyright (c) 2025 Timur Bikulov, Mohamad-Bilal Abbas, Hans-Joachim Krause, Andreas Offenhäusser, Ulrich Engelmann

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Magnetic Particle Spectroscopy (MPS) allows for direct characterization of magneto-physical properties of magnetic nanoparticles (MNP), which are widely researched as imaging tracers, biosensing units and therapeutic heating agents. All these applications rely primarily on the core size-dependent magnetic particle relaxation dynamics. Therefore, knowledge about core size of any MNP sample is crucial. Dual-frequency MPS increases the characterization potential by considering frequency mixing terms of the received signal of MNP, from which their sizes can be approximated. In this work, preliminary feasibility and interpretation of a proposed size reconstruction method is tested against precisely simulated input data from stochastically coupled Néel-Brownian relaxation modeling using Monte Carlo implementation.

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