International Journal on Magnetic Particle Imaging IJMPI
Vol. 11 No. 1 Suppl 1 (2025): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2025.2503029

Proceedings Articles

Measurement of cerebral blood volume modulation in non-human primates

Main Article Content

Alex C. Barksdale (1)Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, USA; 2)Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA), Frauke H. Niebel (1) Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA; 2)Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering IMTE, Lübeck, Germany; 3)Institute of Medical Engineering, University of Lübeck, Lübeck, Germany), Jorge Chacon-Caldera (1) Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA; 2)Harvard Medical School, Boston, MA, USA), Monika Śliwiak (1) Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA), John M. Drago (1) Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, USA; 2) Harvard Medical School, Boston, MA, USA; 3)arvard-MIT Division of Health Sciences & Technology, Cambridge, MA, USA), Eli Mattingly (1) Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA; 2)Harvard-MIT Division of Health Sciences & Technology, Cambridge, MA, USA), Matthias Graeser (1)Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering IMTE, Lübeck, Germany; 2)Chair of Measurement Technology, University Rostock, Rostock, Germany), Hong P. Deng (1) Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA; 2)Harvard Medical School, Boston, MA, USA), Joseph B. Mandeville (1) Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA; 2)Harvard Medical School, Boston, MA, USA), Lawrence L. Wald (1) Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA; 2)Harvard Medical School, Boston, MA, USA; 3)Harvard-MIT Division of Health Sciences & Technology, Cambridge, MA, USAdd)

Copyright (c) 2025 Alex C. Barksdale, Frauke H. Niebel, Jorge Chacon-Caldera, Monika ?liwiak, John M. Drago, Eli Mattingly, Matthias Graeser, Hong P. Deng, Joseph B. Mandeville, Lawrence L. Wald

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

MPI offers a promising alternative to fMRI for detecting changes in cerebral blood volume (CBV) during brain activation, potentially enabling single-patient functional brain mapping. We assess our human-scale MPI brain scanner by imaging anesthetized non-human primates, achieving continuous imaging with 5 s temporal and 7 mm spatial resolution. We successfully detect CBV modulations during alternating cycles of hypercapnia and normocapnia, achieving a CNR of up to 7.9 following activations in the brain region.

Article Details

References

[1] B. Gleich and J. Weizenecker. Tomographic imaging using the non- linear response of magnetic particles. Nature, 435(7046):1214–1217, 2005, doi:10.1038/nature03808.
[2] C. Billings, M. Langley, G. Warrington, F. Mashali, and J. A. John- son. Magnetic particle imaging: Current and future applications, magnetic nanoparticle synthesis methods and safety measures. International Journal of Molecular Sciences 2021, Vol. 22, Page 7651, 22:7651, 14 2021, doi:10.3390/IJMS22147651.
[3] E. E. Mason, E. Mattingly, K. Herb, S. F. Cauley, M. Sliwiak, J. M. Drago, M. Graeser, E. T. Mandeville, J. B. Mandeville, and L. L. Wald. Functional magnetic particle imaging (fmpi) of cerebrovascular changes in the rat brain during hypercapnia. Physics in Medicine and Biology, 68:175032, 17 2023, doi:10.1088/1361-6560/ACECD1.
[4] T. A. Le, M. P. Bui, Y. Hadadian, K. M. Gadelmowla, S. Oh, C. Im, S. Hahn, and J. Yoon. Towards human-scale magnetic particle imaging: Development of the first system with superconductor- based selection coils. IEEE Transactions on Medical Imaging, 2024, doi:10.1109/TMI.2024.3419427.
[5] E. Mattingly, M. S ?liwiak, J. Chacon-Caldera, A. C. Barksdale, F. H. Niebel, E. E. Mason, and L. L. Wald. A human-scale magnetic par- ticle imaging system for functional neuroimaging. International Journal on Magnetic Particle Imaging IJMPI, 10, 1 Suppl 1 2024, doi:10.18416/IJMPI.2024.2403016.
[6] M. Graeser, F. Thieben, P. Szwargulski, F. Werner, N. Gdaniec, M. Boberg, F. Griese, M. Möddel, P. Ludewig, D. van de Ven, O. M. We- ber, O. Woywode, B. Gleich, and T. Knopp. Human-sized magnetic particle imaging for brain applications. Nature Communications 2019 10:1, 10:1–9, 1 2019, doi:10.1038/s41467-019-09704-x.
[7] F. Thieben, F. Foerger, F. Mohn, N. Hackelberg, M. Boberg, J.-P. Scheel, M. Möddel, M. Graeser, and T. Knopp. System characteri- zation of a human-sized 3d real-time magnetic particle imaging scanner for cerebral applications. Communications Engineering 2024 3:1, 3:1–17, 1 2024, doi:10.1038/s44172-024-00192-6.
[8] P. Vogel, M. A. Rückert, C. Greiner, J. Günther, T. Reichl, T. Kampf, T. A. Bley, V. C. Behr, and S. Herz. Impi: Portable human- sized magnetic particle imaging scanner for real-time endovas- cular interventions. Scientific Reports 2023 13:1, 13:1–14, 1 2023, doi:10.1038/s41598-023-37351-2.

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