International Journal on Magnetic Particle Imaging IJMPI
Vol. 11 No. 1 Suppl 1 (2025): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2025.2503002
Magnetic Phase-Change Nanodroplets for Magnetic Particle Imaging and Magnetic Vaporization
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Copyright (c) 2025 Damla Alptekin Soydan, Sefa Karaca, Gökçen Birlik Demirel, Can Bar?? Top
This work is licensed under a Creative Commons Attribution 4.0 International License.
Abstract
Phase-change nanodroplets (PCNs) are high-potent theragnostic agents for efficient and targeted drug delivery. PCNs can be functionalized to accumulate in tumors, and vaporized by external stimuli. Ultrasound (US) is the primary method for PCN vaporization and imaging. However, it has limitations due to wave propagation effects, relatively high vaporization pressure, and low scattering cross section of PCNs in the liquid phase. Here, we report magnetic phase-change nanodroplets (MPCNs) suitable for magnetic particle imaging (MPI) and vaporization with magnetic heating. MPCNs can enable quantitative monitoring of accumulation in the disease site using MPI, and vaporization with targeted magnetic heating, thereby improving the clinical potential of PCNs as a theragnostic agent.
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