International Journal on Magnetic Particle Imaging IJMPI
Vol. 11 No. 1 Suppl 1 (2025): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2025.2503038
Multi-color MPI for distinguishing two different MNP systems following cellular uptake
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Copyright (c) 2025 Amani Remmo, Olaf Kosch, Lena Kampen, Antje Ludwig, Frank Wiekhorst, Norbert Löwa
This work is licensed under a Creative Commons Attribution 4.0 International License.
Abstract
To demonstrate the capability of multi-color magnetic particle imaging (MPI) to distinguish different magnetic nanoparticle (MNP) systems after cellular uptake, we investigated two distinct MNP samples following uptake by THP-1 monocytes. Magnetic particle spectroscopy (MPS) and MPI were employed to characterize the unique magnetic signatures of each MNP-labeled cell sample, allowing for clear differentiation. These findings establish the basis for future applications in tracking specific monocyte subpopulations, thereby enabling detailed investigation of immune cell functions and migration patterns within inflammatory processes.