International Journal on Magnetic Particle Imaging IJMPI
Vol. 11 No. 1 Suppl 1 (2025): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2025.2503038

Proceedings Articles

Multi-color MPI for distinguishing two different MNP systems following cellular uptake

Main Article Content

Amani Remmo (Phd Student), Olaf Kosch (Physikalisch-Technische Bundesanstalt Berlin), Lena Kampen (Charité-Universitätsmedizin Berlin), Antje Ludwig (Charité-Universitätsmedizin Berlin), Frank Wiekhorst (Physikalisch-Technische Bundesanstalt Berlin), Norbert Löwa (Physikalisch-Technische Bundesanstalt Berlin)

Abstract

To demonstrate the capability of multi-color magnetic particle imaging (MPI) to distinguish different magnetic nanoparticle (MNP) systems after cellular uptake, we investigated two distinct MNP samples following uptake by THP-1 monocytes. Magnetic particle spectroscopy (MPS) and MPI were employed to characterize the unique magnetic signatures of each MNP-labeled cell sample, allowing for clear differentiation. These findings establish the basis for future applications in tracking specific monocyte subpopulations, thereby enabling detailed investigation of immune cell functions and migration patterns within inflammatory processes.

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