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The development of suitable tracers with optimized characteristics is a crucial factor to bring the powerful and high-innovative technology of Magnetic Particle Imaging further towards clinics. Successful engineering of new magnetic particles for this imaging method requires a deeper understanding of structure-performance relationships. Even though many international research groups work in the field of tracer development for the MPI technology, until now no economic and reproducible synthesis method was found to produce high-performance tracer materials with optimal characteristics. In the present work recent achievements in the continuous synthesis of single-core iron oxide nanoparticles with tunable characteristics employing a micromixer set-up are reported.