Evaluation of casein coated iron oxide magnetic nanoparticles

Nils Meier; Christina Wenck; Regina Bleul; Frank Wiekhorst

doi:10.18416/IJMPI.2025.2503003

International Journal on Magnetic Particle Imaging IJMPI
Vol. 11 No. 1 Suppl 1 (2025): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2025.2503003

Proceedings Articles

Evaluation of casein coated iron oxide magnetic nanoparticles

Nils Meier (Fraunhofer Institute for Microengineering and Microsystems IMM, Carl-Zeiss-Str. 18-20, 55129 Mainz, Germany), Christina Wenck (1) Fraunhofer Institute for Microengineering and Microsystems IMM, Carl-Zeiss-Str. 18-20, 55129 Mainz, Germany), Regina Bleul (Fraunhofer Institute for Microengineering and Microsystems IMM, Carl-Zeiss-Str. 18-20, 55129 Mainz, Germany), Frank Wiekhorst (Metrology for Magnetic Nanoparticles, Physikalisch-Technische Bundesanstalt, Abbestr. 2-12, 10587 Berlin, Germany)

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Theranostic systems offer a promising approach for early cancer diagnosis and treatment. Here we report the investigation of Na-caseinate-coated iron oxide magnetic nanoparticles (MNP) for potential use in theranostics. The MNP were synthesized in a continuous flow, coated with Na-caseinate, and crosslinked enzymatically for improved stability and drug loading. To evaluate their magnetic suitability for magnetic particle imaging (MPI) and hyperthermia, we conducted DC magnetization measurements, magnetic particle spectroscopy (MPS), and AC-magnetometry. Results show that Na-caseinate coating has minimal impact on magnetic behavior, with a stable magnetization saturation (Ms) of 109(5) A·m²/kg(Fe) for both coated and uncoated particles. The MPI signal (A3*) decreased by less than 15%, with a slight 2% drop in the A5/A3 ratio. Additionally, Na-caseinate coating improved salt stability without altering magnetic performance, supporting their potential for theranostic applications in drug delivery, MPI, and hyperthermia.

References

[1] P. Farinha et al., A Comprehensive Updated Review on Magnetic Nanoparticles in Diagnostics, Nanomaterials, 2021, 11 , 3432, DOI: 10.3390/nano11123432.
[2] M. Salim et al., Opportunities for milk and milk-related systems as 'new' low-cost excipient drug delivery materials, Advanced Drug Delivery Reviews, 2022, 183, 114139, DOI: 0.1016/j.addr.2022.114139.
[3] C. Wenck and N. Meier et al., Design and characterisation of casein coated and drug loaded magnetic nanoparticles for theranostic applications, RSC Advances, 2024, 14, 26388-26399, DOI: 10.1039/D4RA02626H.

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