International Journal on Magnetic Particle Imaging IJMPI
Vol. 11 No. 1 Suppl 1 (2025): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2025.2503006

Proceedings Articles

Magnetic particle spectroscopy based biosensing platform for nucleic acids detection

Main Article Content

Florian Wolgast (Institute for Electrical Measurement Science and Fundamental Electrical Engineering (EMG) and Laboratory for Emerging Nanometrology (LENA), TU Braunschweig, Braunschweig, Germany), Rebecca Sack (Institute for Electrical Measurement Science and Fundamental Electrical Engineering (EMG) and Laboratory for Emerging Nanometrology (LENA), TU Braunschweig, Braunschweig, Germany), Yihao Wang (Institute for Electrical Measurement Science and Fundamental Electrical Engineering (EMG) and Laboratory for Emerging Nanometrology (LENA), TU Braunschweig, Braunschweig, Germany), Rabia Amin (Institute for Electrical Measurement Science and Fundamental Electrical Engineering (EMG) and Laboratory for Emerging Nanometrology (LENA), TU Braunschweig, Braunschweig, Germany), Mohammad Suman Chowdhury (Institute for Electrical Measurement Science and Fundamental Electrical Engineering (EMG) and Laboratory for Emerging Nanometrology (LENA), TU Braunschweig, Braunschweig, Germany), Aidin Lak (Institute for Electrical Measurement Science and Fundamental Electrical Engineering (EMG) and Laboratory for Emerging Nanometrology (LENA), TU Braunschweig, Braunschweig, Germany), Meinhard Schilling (Institute for Electrical Measurement Science and Fundamental Electrical Engineering (EMG) and Laboratory for Emerging Nanometrology (LENA), TU Braunschweig, Braunschweig, Germany), Thilo Viereck (Institute for Electrical Measurement Science and Fundamental Electrical Engineering (EMG) and Laboratory for Emerging Nanometrology (LENA), TU Braunschweig, Braunschweig, Germany)

Copyright (c) 2025 Florian Wolgast, Rebecca Sack, Yihao Wang, Rabia Amin, Mohammad Suman Chowdhury, Aidin Lak, Meinhard Schilling, Thilo Viereck

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Reliable nucleic acid assays are essential for modern laboratory diagnostics. Due to the complex and numerous steps involved, polymerase chain reaction, the current gold standard in nucleic acid detection, is not suitable for point-of-care (POC) diagnostics. Assays based on magnetic nanoparticles (MNPs) and magnetic particle spectroscopy (MPS) are wash- and enzyme-free and combine signal amplification with a benchtop device, thus fulfilling all the requirements to close this gap. Our nucleic acids biosensing platform enables the specific detection of DNA in concentrations of less than 27 pM as well as the enzyme-free detection of viral RNA in combination with a highly sensitive MPS device with cost-effective technology.

Article Details

References

[1] E. L. Rösch et al., Amplification- and Enzyme-Free Magnetic Diagnostics Circuit for Whole-Genome Detection of SARS-CoV-2 RNA, ChemBioChem, vol. 25, p. e202400251, June 2024.
[2] F. T. Wolgast et al., Low-Cost Magnetic Particle Spectroscopy Hardware for Low-Viral-Load Immunoassays, IEEE Trans. Instrum. Meas. vol. 73, pp. 6008509, August 2024.
[3] P. Vogel et al., Critical Offset Magnetic Particle Spectroscopy for rapid and highly sensitive medical point-of-care diagnostics, Nat. Commun, vol. 13, pp. 7230, November 2022.

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