A trace doping strategy for developing magnetic nanoparticles magnetic particle imaging and magnetic hyperthermia properties

Abstract

Magnetic particle imaging-guided magnetic hyperthermia therapy (MPI-MHT) allows direct imaging, quantification and prediction of heat production of magnetic nanoparticles at focal sites, guiding target mapping, dose planning and efficacy monitoring of subsequent magnetic hyperthermia therapy, which greatly improves the safety and effectiveness of magnetic hyperthermia therapy. However, due to the performance contradiction between magnetothermal therapy and MPI itself, the currently available magnetic particles fail to balance the needs of both in performance regulation, which greatly hinders the construction of MPI-MHT integrated platform. In this work, we proposed a trace doping strategy to synthesize the magnetic spin ordered and anisotropic tunable nanoprobes. It has been tested to demonstrate unprecedented MPI-MHT capability. It brings great prospects for the construction of MPI-MHT integrated diagnosis and treatment platform, effectively avoiding the harm caused by the increased burden of over-diagnosis and over-treatment.