MPI-based spatio-temporal estimation of a temperature profile induced by an IR laser

Abstract

The separation of signals based on particle type, their environment or temperature has added a useful layer to the foundation of spatial MP imaging. The multi-color approach of signal reconstruction offers a far-reaching option for clinical interventions such as the controllable and precise application of hyperthermia. In this study, a multi-color reconstruction approach was applied to highlight the potential of MPI for temperature monitoring. For this purpose, we heated a solution of SPIO nanoparticles with a high-power laser and reconstructed the corresponding dynamic temperature maps by MPI data acquisition. A good temporal and spatial correlation between the MPI-based temperature maps and fiber optic thermometer measurements was observed.