International Journal on Magnetic Particle Imaging IJMPI
Vol. 9 No. 1 Suppl 1 (2023): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2023.2303066

Proceedings Articles

Development of Optimized Magnetic Particle Imaging Tracers Utilizing Genetically Engineered Magnetosomes

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Florian Thieben (University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute for Biomedical Imaging, Hamburg University of Technology, Hamburg, Germany), Frank Mickoleit (Department of Microbiology, University of Bayreuth, Bayreuth, Germany), Sophia Tessaro (Department of Microbiology, University of Bayreuth, Bayreuth, Germany), Peter Ludewig (University Medical Center Hamburg-Eppendorf, Hamburg, Germany), Dirk Schüler (Department of Microbiology, University of Bayreuth, Bayreuth, Germany), Javier Rández Garbayo (University Medical Center Hamburg-Eppendorf, Hamburg, Germany), René Uebe (Department of Microbiology, University of Bayreuth, Bayreuth, Germany; Department of Microbial Biochemistry, University of Bayreuth, Bayreuth, Germany), Tobias Knopp (University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute for Biomedical Imaging, Hamburg University of Technology, Hamburg, Germany)

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Abstract

The imaging quality of Magnetic Particle Imaging (MPI) is not just limited by the MPI system but also by the quality of available tracers. The tracer quality can be improved by optimizing the shape, core size and shell of the nanoparticles. However, such a defined synthesis is quiet challenging. Biogenic magnetic nanoparticles, so-called magnetosomes, synthesized by magnetotoactic bacteria, might provide a promising alternative. In this study, magnetosomes isolated from different Magnetospirillum gryphiswaldense mutant strains biomineralizing particles with varying core diameters were investigated with regard to their usability as tracers for MPI.

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