OGF-based high-throughput spatial encoding for magnetic particle imaging

Abstract

Enhancing the signal-to-noise ratio (SNR) is crucial for comprehensively improving the performance of MPI, as it can directly enhance detection sensitivity and indirectly improve spatial resolution due to the increase in the number of available harmonics. However, the strong gradient field in the existing MPI system inevitably leads to the loss of SNR. To deal with this problem, we introduce an oscillating gradient field (OGF) to achieve a high-throughput spatial encoding to improve the SNR of MPI. The time-varying gradient strength allows particle signals from both high and low gradient fields to be captured simultaneously over the sampling period. Preliminary simulation results show that the proposed spatial encoding scheme can generate unique intermodulation signals for particles at each position. And compared with static gradient field with the same peak gradient level, OGF can theoretically generate particle signals with higher SNR.