High Performance MPI with Magnetically induced Magnetosome Chains (MAGiCs)

Abstract

In this study, we demonstrate the potential of magnetically induced magnetosome chains (MAGiCs), which are composed of biosynthesized magnetic nanoparticles (MNPs), as the traces for magnetic particle imaging (MPI). The magnetosomes in MAGiC align in an orderly manner under the induction of a uniform magnetic field, and in this state, MAGiC can significantly enhance the MPI imaging quality. MPS result showed that compared to the commercial tracer VivoTrax+, MAGiC achieved a 25-fold improvement in resolution and a 91-fold increase in signal intensity. In 2D MPI, the reconstructed images achieved a resolution of 0.3 mm under a 1.25 T/m gradient field. All images were reconstructed using the x-space algorithm without employing iterative algorithms.