Real-time and high-resolution magnetic particle optical imaging

Abstract

Magnetic nanoparticles (MNPs) have emerged as a promising medical imaging contrast agent due to their nontoxic and non-invasive properties, among others. This suggests that they possess significant potential for future applications. However, when it comes to imaging dynamic and rapid physiological processes, real-time visualization becomes crucial. In order to address this challenge, we propose a magnetic particle optical imaging (MPOI) approach that enables real-time imaging of MNPs under the influence of an external magnetic field. Our experimental results demonstrate that MPOI can achieve a frame rate of 20 frames per second (FPS), allowing for the accurate tracking of the movement of a copper wire within an MNPs suspension. This finding highlights the spatial resolution and real-time performance advantages of the MPOI method. Consequently, this method opens up exciting possibilities for the real-time imaging of various rapid physiological activities in the future.