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The first two manuscripts in this second issue of the second volume of the International Journal on Magnetic Particle Imaging are covering novel reconstruction techniques. While there are already established methods available the very young field of magnetic particle imaging (MPI) still offers much room for new concepts and algorithms to improve image quality, quantification, or processing speed. The remaining manuscripts are dealing with measurements obtaining additional information on top of tracer localization and the study of magnetic nanoparticle processing in organisms to help establish MPI as a clinical diagnostic tool.